DEPARTMENT OF MENTAL HEALTH:
Learning Disability
HEAD: Professor Sheila C. Hollins FRCPsych
St George’s Hospital Medical School
UNIVERSITY OF LONDON
Overview of FAS
by Raja Mukherjee
Foetal Alcohol Syndrome (FAS) is a
neurodevelopmental disorder caused by the use of alcohol during pregnancy. It
is associated with both a physical phenotype as well as a life long behavioural
phenotype, which is both pervasive and debilitating for the majority of people
suffering with the condition.
How common is it?
Reports suggest varying rates of
prevalence of the disorder. The full disorder of foetal alcohol syndrome is
thought to have a prevalence of around 1 in 3000. This compares to other
conditions such as Downs Syndrome 1 in 666, Phenylketonuria 1 in 14000, Fragile
X 1 in 1000. Unlike these conditions and more similar to the picture seen in
autism there appears to be a spectrum of problems from the most severe
presentation of the full condition to a milder but still significant impairment
of behaviour. This Spectrum (Foetal Alcohol Spectrum Disorder FASD) is
estimated to have a prevalence of around 1 in 300. Also unlike the other
conditions mentioned which also have behavioural and physical phenotypes FAS is
not a genetic condition and thus is eminently preventable.
Most of the research on the
incidence of this condition has occurred in America with studies also being
carried out in South Africa and Scandinavia. What these have shown is that the
prevalence is broadly comparable and thus it would be expected that similar rates
would be found in the UK. Work needs to occur in this country to try and
clarify if this is the case. A potential problem that exists currently is that
studies show that young females in this country are partaking more in binge
drinking. If this occurs at a time of venerability during pregnancy (see below)
it will potentially lead to an increase in prevalence.
Who is at risk of developing this?
Everyone who drinks during pregnancy is potentially at risk. Studies to date have shown
that the most common group to have children with foetal alcohol syndrome are
people who drink chronically during pregnancy. There is an increasing
literature of evidence, however to suggest that binge drinking as well as low
doses of alcohol can cause damage. This may not be to the extent that would
cause the full disorder but it is speculated that the behavioural problems will
present themselves in individuals who are exposed to levels of alcohol in
pregnancy. Specific venerable periods also exist during pregnancy when the foetus
is more or less at risk of developing some of the phenotypic features, however
as the brain develops throughout pregnancy there is no safe period for
consumption in pregnancy. Due to the ethical problems of studying this in
humans no specific data as to the exact safe level exists thus this data is
extrapolated from animal models. The only definitely safe level is no alcohol
at all.
How is this diagnosed?
Anecdotal evidence would suggest that it is
under recognised and labelled more as ADHD or Conduct Disorder in childhood.
This potentially leads to a diagnosis in some of personality disorder in
adulthood. Whilst this is an acceptable diagnosis it misses the specific cause
of the problem. Diagnosis can be made in one of two ways. Firstly by definition
of a series of symptoms leading to a syndromal diagnosis. The second is in
terms of an aetiological cause. ADHD would be considered a diagnosis of the
former category and FAS the second. AS such rather than being mutually
exclusive they are very likely to exist concurrently as diagnoses in a
multiaxial fashion. This is more recognised as an appropriate way of making
diagnoses.
Studies are currently being conducted by myself
and others looking into the nature as to how well recognised FAS is by multi professional
groups.
Do people get better?
FAS is a pervasive disorder. This
means that is will never be cured and will never go away. It affects the basic
structure of the brain and the way that it processes information. This is
similar to Autism and other pervasive developmental disorders. Having said this
unlike autism, with which the behavioural phenotype has some crossover, a
majority of people have an IQ in normal range. Only 25 - 30% of people with FAS have an intellectual
disability. A majority will however suffer with behaviour problems.
AS with other conditions however
studies in Germany and Scandinavia have shown that consistency and family
support can lead to a better outcome. Also education especially in social
skills can be of benefit. Many will still find it difficult and need lifelong
support but some will be able to live normal lives in the community.
Is this a condition that needs
support and awareness
FAS is by far the largest
preventable cause of intellectual disability that exists. It is an ongoing
financial burden to healthcare providers and in some cases to the criminal
justice system. Awareness of this condition currently is minimal and thus more
work both with health promotion campaigns and support for those already
suffering with this disorder are vital.
Please note I have not included scientific references in this overview
but would be happy to do so if requested.
Raja Mukherjee
Specialist Registrar/ Honorary
Lecturer
Department of Mental Health (
Learning Disability)
St George’s Hospital Medical
School, Cranmer Terrace, Tooting
London, SW17 0RE